Strategies for targeting senescent cells in human disease
Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”
Abstract Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
SM Lagoumtzi, N Chondrogianni - Free Radical Biology and Medicine, 2021 - Elsevier
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …
environmental factors, characterizing many types of somatic cells. It has been suggested as …
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
K Evangelou, PVS Vasileiou… - Physiological …, 2023 - journals.physiology.org
Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …
immense impact on patient quality of life and disability. Clinical evidence has revealed a …
A two-pronged detection of atherosclerosis with a dual-channel fluorescent probe for viscosity and hypochlorous acid
The precise detection of atherosclerosis has been a research hot point since its importance
in the diagnosis of cardiovascular diseases. Here we synthesized a near-infrared …
in the diagnosis of cardiovascular diseases. Here we synthesized a near-infrared …
Connecting aging biology and inflammation in the omics era
KA Walker, N Basisty, DM Wilson… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches
Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …
Relationship between sarcopenia and cardiovascular diseases in the elderly: an overview
N He, Y Zhang, L Zhang, S Zhang, H Ye - Frontiers in cardiovascular …, 2021 - frontiersin.org
With the advent of population aging, aging-related diseases have become a challenge for
governments worldwide. Sarcopenia has defined as a clinical syndrome associated with …
governments worldwide. Sarcopenia has defined as a clinical syndrome associated with …
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Y Sun, X Wang, T Liu, X Zhu, X Pan - Cell & bioscience, 2022 - Springer
Background The global population of older individuals is growing, and ageing is a key risk
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …