Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies
Neural cell death is the main feature of all retinal degenerative disorders that lead to
blindness. Despite therapeutic advances, progression of retinal disease cannot always be …
blindness. Despite therapeutic advances, progression of retinal disease cannot always be …
The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems
Diseases that result in retinal pigment epithelium (RPE) degeneration, such as age-related
macular degeneration (AMD), are among the leading causes of blindness worldwide …
macular degeneration (AMD), are among the leading causes of blindness worldwide …
Comparative biology of vertebrate retinal regeneration: restoration of vision through cellular reprogramming
The regenerative capacity of the vertebrate retina varies substantially across species.
Whereas fish and amphibians can regenerate functional retina, mammals do not. In this …
Whereas fish and amphibians can regenerate functional retina, mammals do not. In this …
Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina
K Emmerich, DT White, SP Kambhampati… - Communications …, 2023 - nature.com
Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals.
However, insights gleaned from zebrafish have been applied to stimulate nascent …
However, insights gleaned from zebrafish have been applied to stimulate nascent …
Glycogen synthase kinase 3 signaling in neural regeneration in vivo
Abstract Glycogen synthase kinase 3 (GSK3) signaling plays important and broad roles in
regulating neural development in vitro and in vivo. Here, we reviewed recent findings of …
regulating neural development in vitro and in vivo. Here, we reviewed recent findings of …
VEGF mediates retinal Müller cell viability and neuroprotection through BDNF in diabetes
YZ Le, B Xu, AJ Chucair-Elliott, H Zhang, M Zhu - Biomolecules, 2021 - mdpi.com
To investigate the mechanism of vascular endothelial growth factor (VEGF) and brain-
derived neurotrophic factor (BDNF) in Müller cell (MC) viability and neuroprotection in …
derived neurotrophic factor (BDNF) in Müller cell (MC) viability and neuroprotection in …
Therapeutic effects of mesenchymal stem cells-derived extracellular vesicles' miRNAs on retinal regeneration: a review
Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted
from all cells to transform vital information in the form of lipids, proteins, mRNAs and small …
from all cells to transform vital information in the form of lipids, proteins, mRNAs and small …
GSK3 is a central player in retinal degenerative diseases but a challenging therapeutic target
Glycogen synthase kinase 3 (GSK3) is a key regulator of many cellular signaling processes
and performs a wide range of biological functions in the nervous system. Due to its central …
and performs a wide range of biological functions in the nervous system. Due to its central …
[HTML][HTML] New insight of Müller glial cells functions: focus on microRNAs-dependent manner
W Jiang, S He, L Liu, X Meng, J Lu, J Li… - British Journal of …, 2023 - bjo.bmj.com
MicroRNAs belong to the family of non-coding RNAs that participate in cell proliferation, cell
death and development. The Müller glial cells are the inherent and specific neuroglia cells in …
death and development. The Müller glial cells are the inherent and specific neuroglia cells in …
Far from home: the role of glial mRNA localization in synaptic plasticity
Neurons and glia are highly polarized cells, whose distal cytoplasmic functional subdomains
require specific proteins. Neurons have axonal and dendritic cytoplasmic extensions …
require specific proteins. Neurons have axonal and dendritic cytoplasmic extensions …