Insertional mutagenesis was applied to Cryptococcus neoformans to identify genes
associated with virulence attributes. Using biolistic transformation, we generated 4,300 …

Why do only certain microbes have the capacity to be virulent, and why are certain microbes
virulent only in certain hosts? These fundamental questions have shaped and directed the …

The morbidity, mortality and economic burden associated with fungal infections, together
with the emergence of fungal strains resistant to current antimicrobial agents, necessitate …

Cryptococcus neoformans and Cryptococcus gattii are the cause of life-threatening
meningoencephalitis in immunocompromised and immunocompetent individuals …

Fungi are relatively rare causes of life-threatening systemic disease in immunologically
intact mammals despite being frequent pathogens in insects, amphibians, and plants. Given …

Organic farming strategy is growing rapidly all over the world to conserve human health and
the environment, which became under risk because of the unbalance use of pesticides and …

During the long history of co-evolution with protists, bacteria have evolved defense
strategies to avoid grazing and survive phagocytosis. These mechanisms allow bacteria to …

Over recent years we have witnessed the emergence of several non-vertebrate mini-hosts
as alternative pathosystems for the study of fungal disease. These heterologous organisms …

Non-mammalian hosts have been used to study host–fungal interactions. Hosts such as
Drosophila melanogaster, Caenorhabditis elegans, Acathamoeba castellanii, Dictyostelium …

Cryptococcus neoformans is a fungal pathogen that has evolved over the past 40 million
years into three distinct varieties or sibling species (gattii, grubii, and neoformans). Each …