The haploid social soil amoeba Dictyostelium discoideum has been established as a host
model for several pathogens including Pseudomonas aeruginosa, Cryptococcus …

Filamentous fungi represent classical examples for environmentally acquired human
pathogens whose major virulence mechanisms are likely to have emerged long before the …

The social amoeba Dictyostelium discoideum is increasingly being used as a simple model
for the investigation of problems that are relevant to human health. This article focuses on …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

We have studied infection of Cryptococcus neoformans in the non-vertebrate host Galleria
mellonella with particular interest in the morphological response of the yeast. Inoculation of …

After inhalation of infectious particles, Cryptococcus neoformans resides in the alveolar
spaces, where it can survive and replicate in the extracellular environment. This yeast has …

Amoeboid predators, such as amoebae, are proposed to select for survival traits in soil
microbes such as Cryptococcus neoformans; these traits can also function in animal …

The fungal kingdom is vast, spanning∼ 1.5 to as many as 5 million species diverse as
unicellular yeasts, filamentous fungi, mushrooms, lichens, and both plant and animal …

Phagocytosis is a receptor-mediated process that leads to the internalization of foreign
particles into phagocytic cells. Phagocytic cells, such as macrophages, dendritic cells, and …

Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …