Synopsis of some recent tactical application of bioisosteres in drug design

NA Meanwell - Journal of medicinal chemistry, 2011 - ACS Publications
The concept of isosterism between relatively simple chemical entities was originally
contemplated by James Moir in 1909, a notion further refined by HG Grimm's hydride …

[HTML][HTML] Spectroscopic determination of acetylcholine (ACh): a representative review

P Świt, A Pollap, J Orzeł - Topics in Current Chemistry, 2023 - Springer
Acetylcholine (ACh) is one of the most crucial neurotransmitters of the cholinergic system
found in vertebrates and invertebrates and is responsible for many processes in living …

Amine-Capped ZnS−Mn2+ Nanocrystals for Fluorescence Detection of Trace TNT Explosive

R Tu, B Liu, Z Wang, D Gao, F Wang, Q Fang… - Analytical …, 2008 - ACS Publications
Mn2+-doped ZnS nanocrystals with an amine-capping layer have been synthesized and
used for the fluorescence detection of ultratrace 2, 4, 6-trinitrotoluene (TNT) by quenching …

[HTML][HTML] I5 polymers with a layered arrangement: synthesis, spectroscopy, and structure of a new polyiodide salt in the nicotine/HI/I2 system

GJ Reiss - Zeitschrift für Naturforschung B, 2015 - degruyter.com
The reaction of S-nicotine with hydroiodic acid in the presence of iodine gave the new
polyiodide-containing salt nicotine-1, 1′-diium bis (triiodide)-diiodine (1/1)(C10H16N2)[I3] …

The influence of bioisosteres in drug design: tactical applications to address developability problems

NA Meanwell - Tactics in Contemporary Drug Design, 2015 - Springer
The application of bioisosteres in drug discovery is a well-established design concept that
has demonstrated utility as an approach to solving a range of problems that affect candidate …

Experimental observation of the transition between gas-phase and aqueous solution structures for acetylcholine, nicotine, and muscarine ions

M Seydou, G Grégoire, J Liquier… - Journal of the …, 2008 - ACS Publications
Structural information on acetylcholine and its two agonists, nicotine, and muscarine has
been obtained from the interpretation of infrared spectra recorded in the gas-phase or in low …

Nicotine Refined: Crystal Engineering of (S)-Nicotinium Malate Salts

DJ Angevine, KJ Camacho, J Rzayev… - Crystal Growth & …, 2022 - ACS Publications
Nicotine, a widely consumed, yet considered toxic, active pharmaceutical ingredient for
recreational use, is known to rapidly deteriorate into unwanted and potentially harmful side …

A Theoretical Evaluation of the pKHB and Δ H\,⊖\hfill\rmHB\hfill Hydrogen‐Bond Scales of Nitrogen Bases

F Besseau, J Graton, M Berthelot - Chemistry–A European …, 2008 - Wiley Online Library
The experimental pKHB hydrogen‐bond (HB) basicity scale and the corresponding Δ
H⊖\hfill\rmHB\hfill enthalpic scale of nitrogen compounds are extended and analysed in light …

A selective fluorescent resonance energy transfer quenching and resonance light scattering enhancement dual-recognition probe for 2, 4, 6-trinitrotoluene

WS Zou, FH Zou, Q Shao, J Zhang, YQ Wang… - … of Photochemistry and …, 2014 - Elsevier
Fluorescein isothiocyanate (FITC) conjugated to polyethylenimine (PEI)(FITC&PEI) was
synthesized and characterized. The nitrogen-containing organic groups played a key role in …

[PDF][PDF] Crystal structures and hydrogen bonding in the proton-transfer salts of nicotine with 3, 5-dinitrosalicylic acid and 5-sulfosalicylic acid

G Smith, UD Wermuth - Acta Crystallographica Section E: Structure …, 2014 - journals.iucr.org
The structures of the 1: 1 anhydrous salts of nicotine (NIC) with 3, 5-dinitrosalicylic acid
(DNSA) and 5-sulfosalicylic acid (5-SSA), namely (1R, 2S)-1-methyl-2-(pyridin-3-yl)-1H …