Protein activity and turnover is tightly and dynamically regulated in living cells. Whereas the
three-dimensional protein structure is predominantly determined by the amino acid …

The identification of tau protein as a major constituent of neurofibrillary tangles spurred
considerable effort devoted to identifying and validating pathways through which …

Lysine acetylation is a major posttranslational modification involved in a broad array of
physiological functions. Here, we provide an organ-wide map of lysine acetylation sites from …

Mitochondrial protein hyperacetylation is a known consequence of sustained ethanol
consumption and has been proposed to play a role in the pathogenesis of alcoholic liver …

Post-translational modifications (PTMs) of histone tails play a key role in epigenetic
regulation of gene expression in a range of organisms from yeast to human; however, little is …

The advent of proteomics techniques for protein identification (PrI) represented a major step
forward in protein chemistry, 1, 2 and indeed, a legion of laboratories are now using different …

Protein acetylation plays a critical regulatory role in eukaryotes but until recently its
significance and function in bacteria and the archaea were obscure. It is now clear, however …

Protein acetylation is an important and reversible post-translational modification (PTM), and
it governs a variety of cellular dynamics and plasticity. Experimental identification of …

Protein acetylation is a widespread modification that is mediated by site-selective
acetyltransferases. KATs (lysine N ϵ-acetyltransferases), modify the side chain of specific …

Histone methylation represents one of the most critical epigenetic events in DNA function
regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide …