Chronic pain and prescription opioid abuse are extremely prevalent in the United States and
worldwide. The consequences of opioid misuse can be life-threatening with significant …

Over recent years there has been a growing need for patients to be sent home from hospital
with prescribed opioids for ongoing management of their acute pain. Increasingly complex …

Importance In an effort to reduce wide-scale abuse of the proprietary oxycodone
hydrochloride formulation OxyContin, an abuse-deterrent formulation (ADF) was introduced …

Purpose The purpose of this study is to assess positive predictive value (PPV), relative to
medical chart review, of International Classification of Diseases (ICD)‐9/10 diagnostic codes …

Oral drug delivery is the most common route of drug administration. Nevertheless, there are
some important limitations that reinforce the need for developing new drug delivery systems …

In the past twenty years, the consumption of opioid medications has reached significant
proportions, leading to a rise in drug misuse and abuse and increased opioid dependence …

Objective Abuse of prescription opioid pain relievers continues to be a serious public health
concern. In contrast to opioids such as oxycodone or morphine, tapentadol, a prescription …

The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled
release of a pharmacologically active ingredient (A) embedded in a matrix comprising a …

Purpose Abuse of opioid analgesics for their psychoactive effects is associated with a large
number of fatalities. The effect of making opioid tablets harder to crush/dissolve on opioid …

Abuse-deterrent opioid formulations have been suggested as one way to decrease the
abuse, addiction, and overdose of orally prescribed opioids. Ten oral opioid formulations …