Reconstructing gene trees from Fitch's xenology relation

M Geiß, J Anders, PF Stadler, N Wieseke… - Journal of mathematical …, 2018 - Springer
Two genes are xenologs in the sense of Fitch if they are separated by at least one horizontal
gene transfer event. Horizonal gene transfer is asymmetric in the sense that the transferred …

The mathematics of xenology: Di-cographs, symbolic ultrametrics, 2-structures and tree-representable systems of binary relations

M Hellmuth, PF Stadler, N Wieseke - Journal of Mathematical Biology, 2017 - Springer
The concepts of orthology, paralogy, and xenology play a key role in molecular evolution.
Orthology and paralogy distinguish whether a pair of genes originated by speciation or …

[HTML][HTML] Resolving prime modules: The structure of pseudo-cographs and galled-tree explainable graphs

M Hellmuth, GE Scholz - Discrete Applied Mathematics, 2024 - Elsevier
The modular decomposition of a graph G is a natural construction to capture key features of
G in terms of a labeled tree (T, t) whose vertices are labeled as “series”(1),“parallel”(0) or …

Orientation of Fitch graphs and reconciliation-free inference of horizontal gene transfer in gene trees

D Schaller, M Hellmuth, PF Stadler - SIAM Journal on Discrete Mathematics, 2023 - SIAM
Horizontal gene transfer (HGT) events partition a gene tree, and thus its leaf set, into subsets
of genes whose evolutionary history is described by speciation and duplication events …

[HTML][HTML] Clustering systems of phylogenetic networks

M Hellmuth, D Schaller, PF Stadler - Theory in Biosciences, 2023 - Springer
Rooted acyclic graphs appear naturally when the phylogenetic relationship of a set X of taxa
involves not only speciations but also recombination, horizontal transfer, or hybridization that …

[HTML][HTML] Best match graphs

M Geiß, E Chávez, M González Laffitte… - Journal of mathematical …, 2019 - Springer
Best match graphs arise naturally as the first processing intermediate in algorithms for
orthology detection. Let T be a phylogenetic (gene) tree T and σ σ an assignment of leaves …

[HTML][HTML] Biologically feasible gene trees, reconciliation maps and informative triples

M Hellmuth - Algorithms for Molecular Biology, 2017 - Springer
Background The history of gene families—which are equivalent to event-labeled gene trees—
can be reconstructed from empirically estimated evolutionary event-relations containing …

[HTML][HTML] Best match graphs and reconciliation of gene trees with species trees

M Geiß, MEG Laffitte, AL Sánchez, DI Valdivia… - Journal of mathematical …, 2020 - Springer
A wide variety of problems in computational biology, most notably the assessment of
orthology, are solved with the help of reciprocal best matches. Using an evolutionary …

Alternative characterizations of Fitch's xenology relation

M Hellmuth, CR Seemann - Journal of mathematical biology, 2019 - Springer
Horizontal gene transfer (HGT) is an important factor for the evolution of prokaryotes as well
as eukaryotes. According to Walter M. Fitch, two genes are xenologs if they are separated by …

[HTML][HTML] From modular decomposition trees to rooted median graphs

C Bruckmann, PF Stadler, M Hellmuth - Discrete Applied Mathematics, 2022 - Elsevier
The modular decomposition of a symmetric map δ: X× X→ Υ (or, equivalently, a set of
pairwise-disjoint symmetric binary relations, a 2-structure, or an edge-colored undirected …