Changing landscape of cannabis: novel products, formulations, and methods of administration

TR Spindle, MO Bonn-Miller, R Vandrey - Current opinion in psychology, 2019 - Elsevier
Laws regulating cannabis have changed radically in the US and abroad. Historically, users
smoked dried cannabis flowers that contained Δ9-tetrahydrocannabinol (THC), the primary …

Analgesic potential of terpenes derived from Cannabis sativa

E Liktor-Busa, A Keresztes, J LaVigne… - Pharmacological …, 2021 - ASPET
Pain prevalence among adults in the United States has increased 25% over the past two
decades, resulting in high health-care costs and impacts to patient quality of life. In the last …

Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex

C Xing, Y Zhuang, TH Xu, Z Feng, XE Zhou, M Chen… - Cell, 2020 - cell.com
Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders,
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions

S Nasrin, CJW Watson, YX Perez-Paramo… - Drug Metabolism and …, 2021 - ASPET
The legalization of cannabis in many parts of the United States and other countries has led
to a need for a more comprehensive understanding of cannabis constituents and their …

The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review

VL Alves, JL Gonçalves, J Aguiar… - Critical Reviews in …, 2020 - Taylor & Francis
The word “cannabinoid” refers to every chemical substance, regardless of structure or origin,
that joins the cannabinoid receptors of the body and brain and that have similar effects to …

Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?

V Martínez, A Iriondo De-Hond, F Borrelli… - International Journal of …, 2020 - mdpi.com
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …

A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma

C Twelves, M Sabel, D Checketts, S Miller… - British journal of …, 2021 - nature.com
Background Preclinical data suggest some cannabinoids may exert antitumour effects
against glioblastoma (GBM). Safety and preliminary efficacy of nabiximols oromucosal …

Pharmacodynamic effects of vaporized and oral cannabidiol (CBD) and vaporized CBD-dominant cannabis in infrequent cannabis users

TR Spindle, EJ Cone, E Goffi, EM Weerts… - Drug and alcohol …, 2020 - Elsevier
Introduction The use and availability of oral and inhalable products containing cannabidiol
(CBD) as the principal constituent has increased with expanded cannabis/hemp …

A systematic review of minor phytocannabinoids with promising neuroprotective potential

NL Stone, AJ Murphy, TJ England… - British Journal of …, 2020 - Wiley Online Library
Embase and PubMed were systematically searched for articles addressing the
neuroprotective properties of phytocannabinoids, apart from cannabidiol and Δ9 …

Cannabidiol (CBD) in cancer management

K O'Brien - Cancers, 2022 - mdpi.com
Simple Summary Cannabidiol (CBD) is one of the main constituents of the plant Cannabis
sativa. Surveys suggest that medicinal cannabis is popular amongst people diagnosed with …