Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …

Background Neuropathic pain is a common and severely disabling state that affects millions
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …

Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …

The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …

The development of novel antiretroviral treatments has led to a significant turning point in the
fight against HIV. Although therapy leads to virologic suppression and prolonged life …

Microglia mediated inflammation contributes to intracerebral hemorrhage (ICH) induced
secondary injury. Activated microglia has dual functions as pro-inflammatory (M1) and anti …

Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

Background Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic
pain. However, the mechanisms underlying spinal microglial activation during neuropathic …

Paclitaxel induces microglial activation and production of proinflammatory mediators in the
dorsal horn, which contribute to the development and maintenance of central sensitization …