Paclitaxel induces microglial activation and production of proinflammatory mediators in the
dorsal horn, which contribute to the development and maintenance of central sensitization …

Cancer-induced bone pain (CIBP) treatment remains a clinical challenge because the
pathophysiological mechanisms are not fully understood. Recently, it was verified that …

Chronic pain is a prevalent neurological complication among individuals living with human
immunodeficiency virus (PLHIV) in the post-combination antiretroviral therapy (cART) era …

Neuropathic pain is still an extremely important problem in today's medicine because
opioids, which are commonly used to reduce pain, have limited efficacy in this type of …

Chemokines and their receptors participate in many biological processes, including the
modulation of neuroimmune interactions. Approximately fifty chemokines are distinguished …

Diabetes is a common condition characterized by persistent hyperglycemia. High blood
sugar primarily affects cells that have a limited capacity to regulate their glucose intake …

Many diseases, including cancer, can lead to neuropathic pain (NP). NP is one of the
accompanying symptoms of suffering in many conditions and the life quality of NP patient is …

Background Postherpetic neuralgia (PHN) is a debilitating complication of herpes zoster,
characterized by persistent neuropathic pain that significantly impairs patients' quality of life …

Neuroinflammation is a key factor that contributes to the secondary damage after cerebral
ischemia/reperfusion (CI/R) injury. Chemokine receptor type 5 (CCR5) has shown its pro …

Background Switching microglial polarization from the pro-inflammatory M1 phenotype to
the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic …