Microtubules provide long tracks along which a broad range of organelles and vesicles are
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …

The axon is the single long fiber that extends from the neuron and transmits electrical
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …

As polarized cells, neurons maintain different sets of resident plasma membrane proteins in
their axons and dendrites, which is consistent with the different roles that these neurites …

Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as
tracks for intracellular transport. Organization and dynamics of the microtubule network are …

Kinesin-1, the founding member of the kinesin superfamily of proteins, is known to use only
a subset of microtubules for transport in living cells. This biased use of microtubules is …

Kinesin-1 is a nanoscale molecular motor that walks towards the fast-growing (plus) ends of
microtubules, hauling molecular cargo to specific reaction sites in cells. Kinesin-driven …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by
more than sixty genes identified through classic linkage analysis and new sequencing …

The motor proteins kinesin and dynein transport organelles, mRNA, proteins, and signaling
molecules along the microtubule cytoskeleton. In addition to serving as tracks for transport …

Heterozygous, missense mutations in both α-and β-tubulin genes have been linked to an
array of neurodevelopment disorders, commonly referred to as “tubulinopathies.” To date …

Microtubules (MTs) and their associated proteins play essential roles in maintaining cell
structure, organelle transport, cell motility, and cell division. Two motors, kinesin and …