Microtubule-based transport and the distribution, tethering, and organization of organelles
K Barlan, VI Gelfand - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Microtubules provide long tracks along which a broad range of organelles and vesicles are
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …
The axonal cytoskeleton: from organization to function
JT Kevenaar, CC Hoogenraad - Frontiers in molecular neuroscience, 2015 - frontiersin.org
The axon is the single long fiber that extends from the neuron and transmits electrical
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …
signals away from the cell body. The neuronal cytoskeleton, composed of microtubules …
The cellular mechanisms that maintain neuronal polarity
M Bentley, G Banker - Nature Reviews Neuroscience, 2016 - nature.com
As polarized cells, neurons maintain different sets of resident plasma membrane proteins in
their axons and dendrites, which is consistent with the different roles that these neurites …
their axons and dendrites, which is consistent with the different roles that these neurites …
Motor usage imprints microtubule stability along the shaft
M Andreu-Carbó, S Fernandes, MC Velluz, K Kruse… - Developmental cell, 2022 - cell.com
Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as
tracks for intracellular transport. Organization and dynamics of the microtubule network are …
tracks for intracellular transport. Organization and dynamics of the microtubule network are …
[HTML][HTML] Kinesin-binding–triggered conformation switching of microtubules contributes to polarized transport
T Shima, M Morikawa, J Kaneshiro… - The Journal of cell …, 2018 - ncbi.nlm.nih.gov
Kinesin-1, the founding member of the kinesin superfamily of proteins, is known to use only
a subset of microtubules for transport in living cells. This biased use of microtubules is …
a subset of microtubules for transport in living cells. This biased use of microtubules is …
Kinesin expands and stabilizes the GDP-microtubule lattice
DR Peet, NJ Burroughs, RA Cross - Nature nanotechnology, 2018 - nature.com
Kinesin-1 is a nanoscale molecular motor that walks towards the fast-growing (plus) ends of
microtubules, hauling molecular cargo to specific reaction sites in cells. Kinesin-driven …
microtubules, hauling molecular cargo to specific reaction sites in cells. Kinesin-driven …
[HTML][HTML] Multiple roles for the cytoskeleton in ALS
X Liu, JL Henty-Ridilla - Experimental neurology, 2022 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by
more than sixty genes identified through classic linkage analysis and new sequencing …
more than sixty genes identified through classic linkage analysis and new sequencing …
Acetylated microtubules are preferentially bundled leading to enhanced kinesin-1 motility
L Balabanian, CL Berger, AG Hendricks - Biophysical journal, 2017 - cell.com
The motor proteins kinesin and dynein transport organelles, mRNA, proteins, and signaling
molecules along the microtubule cytoskeleton. In addition to serving as tracks for transport …
molecules along the microtubule cytoskeleton. In addition to serving as tracks for transport …
The molecular biology of tubulinopathies: Understanding the impact of variants on tubulin structure and microtubule regulation
KJ Hoff, AJ Neumann, JK Moore - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Heterozygous, missense mutations in both α-and β-tubulin genes have been linked to an
array of neurodevelopment disorders, commonly referred to as “tubulinopathies.” To date …
array of neurodevelopment disorders, commonly referred to as “tubulinopathies.” To date …
Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation
Microtubules (MTs) and their associated proteins play essential roles in maintaining cell
structure, organelle transport, cell motility, and cell division. Two motors, kinesin and …
structure, organelle transport, cell motility, and cell division. Two motors, kinesin and …