Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts
before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins …

Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

A central dogma of mammalian reproductive biology is that the size of the primordial follicle
pool represents reproductive capacity in females. The assembly of the primordial follicle …

During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the
somatic and germ cell compartments of the ovarian follicle. The oocyte completes the …

Mammalian oocytes are arrested in meiotic prophase by an inhibitory signal from the
surrounding somatic cells in the ovarian follicle. In response to luteinizing hormone (LH) …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

Low fertility of dairy cattle during the summer in tropical, subtropical and temperate regions
is a well-documented event. A less well-known fact is that during the autumn, although the …

Luteinizing hormone (LH) acts on ovarian follicles to reinitiate meiosis in prophase-arrested
mammalian oocytes, and this has been proposed to occur by interruption of a meioisis …