The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

Comparing the evidence from observational studies and randomized controlled trials for nonskeletal health effects of vitamin D

WB Grant, BJ Boucher, F Al Anouti, S Pilz - Nutrients, 2022 - mdpi.com
Although observational studies of health outcomes generally suggest beneficial effects with,
or following, higher serum 25-hydroxyvitamin D [25 (OH) D] concentrations, randomized …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

An analytical framework for decoding cell type-specific genetic variation of gene regulation

Y Xiao, J Wang, J Li, P Zhang, J Li, Y Zhou… - Nature …, 2023 - nature.com
A deeper understanding of genetic regulation and functional mechanisms underlying
genetic associations with complex traits and diseases is impeded by cellular heterogeneity …

Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms

D Grishin, A Gusev - Nature genetics, 2022 - nature.com
While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …

High-throughput microfluidic droplets in biomolecular analytical system: A review

L Zhang, R Parvin, M Chen, D Hu, Q Fan… - Biosensors and …, 2023 - Elsevier
Droplet microfluidic technology has revolutionized biomolecular analytical research, as it
has the capability to reserve the genotype-to-phenotype linkage and assist for revealing the …

Functional studies of lung cancer GWAS beyond association

E Long, H Patel, J Byun, CI Amos… - Human molecular …, 2022 - academic.oup.com
Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …

[Retracted] Decoding the Mechanism behind the Pathogenesis of the Focal Segmental Glomerulosclerosis

X Zhu, L Tang, J Mao, Y Hameed… - … Methods in Medicine, 2022 - Wiley Online Library
Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease associated with
podocyte injury which is named after the pathologic features of the kidney. The aim of this …

Survey of deep learning techniques for disease prediction based on omics data

X Yu, S Zhou, H Zou, Q Wang, C Liu, M Zang, T Liu - Human Gene, 2023 - Elsevier
In the era of big data, computer science has been applied to every aspect of biomedical
field. At the same time, transforming biomedical data into valuable knowledge is one of the …

Advances in Machine Learning Processing of Big Data from Disease Diagnosis Sensors

S Lu, J Yang, Y Gu, D He, H Wu, W Sun, D Xu, C Li… - ACS …, 2024 - ACS Publications
Exploring accurate, noninvasive, and inexpensive disease diagnostic sensors is a critical
task in the fields of chemistry, biology, and medicine. The complexity of biological systems …