Eukaryotic genomes store information on many levels, including their linear DNA sequence,
the posttranslational modifications of its constituents (epigenetic modifications), and its three …

Highlights•Gene activation involves a complex interplay of many regulatory mechanisms•
Microscopy is indespensable for studying gene regulation•Multi-modal imaging methods are …

In the nucleus, biological processes are driven by proteins that diffuse through and bind to a
meshwork of nucleic acid polymers. To better understand this interplay, we present an …

The contact inhibition of proliferation (CIP) denotes the cell density-dependent inhibition of
growth, and the loss of CIP represents a hallmark of cancer. However, the mechanism by …

Micrococcal nuclease sequencing is the state-of-the-art method for determining chromatin
structure and nucleosome positioning. Data analysis is complex due to the AT-dependent …

In higher eukaryotic cells, a string of nucleosomes, where long genomic DNA is wrapped
around core histones, are rather irregularly folded into a number of condensed chromatin …

Abstract Since Robert Feulgen first stained DNA in the cell, visualizing genome chromatin
has been a central issue in cell biology to uncover how chromatin is organized and behaves …

Genomic information must be faithfully transmitted into two daughter cells during mitosis. To
ensure the transmission process, interphase chromatin is further condensed into mitotic …

Chromatin accessibility is modulated in a variety of ways to create open and closed
chromatin states, both of which are critical for eukaryotic gene regulation. At the single …

The chromatin compaction activity of Polycomb group proteins has traditionally been
considered essential for transcriptional repression. However, there is very little information …