Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

The papillomavirus E2 proteins are pivotal to the viral life cycle and have well characterized
functions in transcriptional regulation, initiation of DNA replication and partitioning the viral …

The papillomavirus E2 protein tethers viral genomes to host mitotic chromosomes to ensure
genome maintenance. We have identified the bromodomain protein Brd4 as a major cellular …

Animal and human papillomaviruses (HPVs) replicate persistently in specific types of
stratified epithelia of their host. After the initial infection, the viral genome replicates at low …

Human papillomavirus (HPV) infections play a crucial role in the pathogenesis of cervical
neoplasia. Insights into the mechanisms by which HPV infection can, in a small numbers of …

Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive
tumors. A subset of these viruses termed 'high risk 'infect the cervix where persistent …

Papillomaviruses establish persistent infection in the dividing, basal epithelial cells of the
host. The viral genome is maintained as a circular, double‐stranded DNA …

ABSTRACT Bromodomain protein 4 (Brd4) has been identified as the cellular binding target
through which the E2 protein of bovine papillomavirus type 1 links the viral genome to …

It has long been recognized that oncogenic viruses often integrate close to common fragile
sites. The papillomavirus E2 protein, in complex with BRD4, tethers the viral genome to host …

The DNA damage response (DDR) maintains genomic integrity through an elaborate
network of signaling pathways that sense DNA damage and recruit effector factors to repair …