The human brain adapts to changing demands by altering its functional and structural
properties (“neuroplasticity”) which results in learning and acquiring skills. Convergent …

The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions,
including attention, inhibitory control, habit formation, working memory and long-term …

The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

Disadvantageous decision‐making and impaired volitional control over actions, thoughts,
and emotions are characteristics of a wide range of mental disorders such as addiction …

“System-level memory consolidation theory” posits that the hippocampus an initially links the
neocortical representations, followed by a shift to a hippocampus-independent neocortical …

Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal
cognitive performance. Despite the fact that many have studied how ACh affects neuronal …

Over the past 20 years there has been a growing interest in the neural underpinnings of
cost/benefit decision-making. Recent studies with animal models have made considerable …

Epidemiological studies reveal that individuals who engage in regular aerobic exercise are
less likely to use and abuse illicit drugs. Until recently, very few studies had examined the …

Addiction represents a complex interaction between the reward and stress neural circuits,
with increasing drug use reflecting a shift from positive reinforcement to negative …

The prelimbic (PL) and infralimbic (IL) medial prefrontal cortex (mPFC) are thought to play
opposing roles in drug‐seeking behaviour. Specifically, the PL promotes drug‐seeking …