Mitogen-activated protein kinases (MAPKs) play a central role in cell signaling. Extracellular
signal-regulated kinase (ERK) is a prototypic subclass of MAPKs and is densely expressed …

Psychostimulant addiction, most notably cocaine and amphetamine-type stimulants are an
important public health problem worldwide. It appears that social factors may influence the …

In the developed and developing world, opioid consumption in combination with alcohol has
become one of the substances abused. In this experiment, we examined the effects of …

Major depression disorder (MDD) is one of the most widespread and debilitating psychiatric
diseases and may be associated with other mental disorders such as anxiety. Despite …

Evidence suggests that the infralimbic cortex (IL), a subregion of the ventromedial prefrontal
cortex (vmPFC), suppresses cocaine‐seeking behavior in a self‐administration paradigm …

Aims This study aims to investigate the pharmacological effects and the underlying
mechanism of cannabidiol (CBD) on methamphetamine (METH)‐induced relapse and …

Addiction is a chronic relapsing disorder and is one of the most important issues in the
world. Changing the level of neurotransmitters and the activities of their receptors, play a …

In humans, cocaine abuse during adolescence poses a significant risk for developing
cognitive deficits later in life. Among the regions responsible for cognitive processes, the …

Chronic drug administration induces neuroplastic changes within brain circuits regulating
cognitive control and/or emotions. Following repeated pairings between drug intake and …

Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in
the trafficking and stabilization of AMPA receptors at synapses within the nucleus …