Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
[HTML][HTML] IUPHAR ECR review: The cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities
X He, A Wedn, J Wang, Y Gu, H Liu, J Zhang… - Pharmacological …, 2024 - Elsevier
Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis …
Z Chen, X Sun, X Li, N Liu - Biochemical Pharmacology, 2023 - Elsevier
Vascular calcification, a prevalent pathological alteration in metabolic syndromes, is tightly
related with cardiometabolic risk events. Ferroptosis, a newly iron-dependent programmed …
related with cardiometabolic risk events. Ferroptosis, a newly iron-dependent programmed …
CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling
M Pan, T Hu, J Lyu, Y Yin, J Sun, Q Wang, L Xu, H Hu… - Autophagy, 2024 - Taylor & Francis
ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1) is the
quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of …
quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of …
Nanoscale Metal–Organic Frameworks‐Mediated Degradation of Mutant p53 Proteins and Activation of cGAS‐STING Pathway for Enhanced Cancer Immunotherapy
L Sun, H Gao, H Wang, J Zhou, X Ji, Y Jiao… - Advanced …, 2024 - Wiley Online Library
Activating cGAS‐STING pathway has great potential to achieve effective antitumor
immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in …
immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in …
Crosstalk between cGAS-STING pathway and autophagy in cancer immunity
Q Lu, Y Chen, J Li, F Zhu, Z Zheng - Frontiers in Immunology, 2023 - frontiersin.org
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is
critical in cancer immunity. Autophagy is a highly conserved process that is responsible for …
critical in cancer immunity. Autophagy is a highly conserved process that is responsible for …
Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway
L Li, F Liu, C Feng, Z Chen, N Zhang… - Chinese Medical …, 2024 - journals.lww.com
Over the past decade, mitochondrial dysfunction has been investigated as a key contributor
to acute and chronic kidney disease. However, the precise molecular mechanisms linking …
to acute and chronic kidney disease. However, the precise molecular mechanisms linking …
[HTML][HTML] Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X
X Zhang, L Han, J Hou, H Yang, H Xu, G Li, Q Shu… - Cell Reports, 2024 - cell.com
Summary Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation
(LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation …
(LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation …
Inhibiting autophagy enhanced mitotic catastrophe-mediated anticancer immune responses by regulating the cGAS-STING pathway
Z Bai, Y Peng, Y Li, Y Zhong, L Chen, Q Guan, W Liu… - Cancer Letters, 2024 - Elsevier
Given the limitations of the response rate and efficacy of immune checkpoint inhibitors (ICIs)
in clinical applications, exploring new therapeutic strategies for cancer immunotherapy is …
in clinical applications, exploring new therapeutic strategies for cancer immunotherapy is …
VRK1 promotes DNA-induced type I interferon production
Z Fan, X Wang, H Cheng, M Pan - Molecular Biology Reports, 2024 - Springer
Abstract Background Type I interferons (IFNs) are an essential class of cytokines with
antitumor, antiviral and immunoregulatory effects. However, over-productive the type I IFNs …
antitumor, antiviral and immunoregulatory effects. However, over-productive the type I IFNs …