Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Bacterial outer membrane vesicles as a platform for biomedical applications: An update
Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and
in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and …
in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and …
Methods for 2-deoxyglycoside synthesis
CS Bennett, MC Galan - Chemical reviews, 2018 - ACS Publications
Deoxy-sugars often play a critical role in modulating the potency of many bioactive natural
products. Accordingly, there has been sustained interest in methods for their synthesis over …
products. Accordingly, there has been sustained interest in methods for their synthesis over …
Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
Biopolymers derived from trees as sustainable multifunctional materials: a review
The world is currently transitioning from a fossil‐fuel‐driven energy economy to one that is
supplied by more renewable and sustainable materials. Trees as the most abundant …
supplied by more renewable and sustainable materials. Trees as the most abundant …
From carbohydrate leads to glycomimetic drugs
B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …
and as structural building blocks, they are fundamental constituents of every cell surface …
A glycobiology review: carbohydrates, lectins and implications in cancer therapeutics
H Ghazarian, B Idoni, SB Oppenheimer - Acta histochemica, 2011 - Elsevier
This review is intended for general readers who would like a basic foundation in
carbohydrate structure and function, lectin biology, and the implications of glycobiology in …
carbohydrate structure and function, lectin biology, and the implications of glycobiology in …
Fluorescence polarization assays in small molecule screening
WA Lea, A Simeonov - Expert opinion on drug discovery, 2011 - Taylor & Francis
Importance of the field: Fluorescence polarization (FP) is a homogeneous method that
allows rapid and quantitative analysis of diverse molecular interactions and enzyme …
allows rapid and quantitative analysis of diverse molecular interactions and enzyme …
Recent advances in antiviral activities and potential mechanisms of sulfated polysaccharides
W Lu, Z Yang, J Chen, D Wang, Y Zhang - Carbohydrate Polymers, 2021 - Elsevier
Natural polysaccharides derived from plants, fungi and animals are well known as ideal
functional products with multiple biological activities and few side effects. Among them …
functional products with multiple biological activities and few side effects. Among them …
Glycosylated gold nanoparticles in point of care diagnostics: From aggregation to lateral flow
AN Baker, GW Hawker-Bond, PG Georgiou… - Chemical Society …, 2022 - pubs.rsc.org
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …