The mitogen-associated protein kinase (MAPK) pathway regulates cell growth and
proliferation; activating mutations in constituent kinases Ras and BRAF promote excessive …

In response to cutaneous infections and inflammation, effector CD8+ T cells enter the
epidermis forming populations of long-lived tissue resident CD8+(T RM) cells. There, they …

A doença de Chagas afeta cerca de 8 milhões de pessoas ao redor do mundo e cerca de
um terço dessas desenvolve as formas graves da doença, sendo o maior caso de …

Persisting high-risk human papillomavirus (HPV) infection is a major cause of cervical
cancer, which develops from cervical intraepithelial neoplasia (CIN).“High-risk” HPVs, in …

While memory CD4 T cells are critical for effective immunity to pathogens, the mechanisms
underlying their generation are poorly defined. Although extensive work has been done to …

Recent studies have shown that Sca-1+(stem cell antigen-1) stem/progenitor cells within
blood vessel walls may contribute to neointima formation, but the mechanism behind their …

Inflammatory agonists differentially activate gene induction of chemokines in endothelial
cells (EC). The molecular mechanisms that produce distinct chemokine induction profiles …

Obliterative bronchiolitis (OB) is the pathology thought to result from chronic lung allograft
rejection. Anti-donor alloimmune T cells have been considered to be the main culprits in …

Abstract Despite Human Leukocyte Antigen (HLA) matching and use of immunosuppressive
drugs, graft-versus-host disease (GVHD) following hematopoietic stem cell transplant …

Within the genus Leishmania there are several member species that are responsible for a
spectrum of human diseases. The so called leishmaniases range in severity from life …