Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Methamphetamine (METH) is an illicit psychostimulant that is abused throughout the world.
METH addiction is also a major public health concern and the abuse of large doses of the …

Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …

The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

Protein accumulation and aggregation with a concomitant loss of proteostasis often
contribute to neurodegenerative diseases, and the ubiquitin–proteasome system plays a …

Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the
related tauopathies, thus targeting tau could be promising for drug development. Proteolysis …

Regulation of protein turnover allows cells to react to their environment and maintain
homeostasis. Proteins can show different turnover rates in different tissue, but little is known …

The production of reactive species is an inevitable by-product of metabolism and thus, life
itself. Since reactive species are able to damage cellular structures, especially proteins, as …

Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of
dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we …

The accumulation of Tau into aggregates is associated with key pathological events in
frontotemporal lobe degeneration (FTD-Tau) and Alzheimer disease (AD). Recent data have …