The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …

The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …

Ongoing social, political and ecological changes in the 21st century have placed more
people at risk of life-threatening acute and chronic infections than ever before. The …

Regulation through post‐translational ubiquitin signaling underlies a large portion of
eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have …

Legionella pneumophila promotes its survival and replication in phagocytes by actively
modulating cellular processes using effectors injected into host cells by its Dot/Icm type IV …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of
the American Legion was the first time that Legionella spp. was identified. Thereafter, the …

Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity
through conserved homeostatic mechanisms. Here we report an exceptionally large and …