Benzodiazepines in Alzheimer's disease: beneficial or detrimental effects

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Dementia is considered a clinical syndrome characterized by cognitive dysfunction and
memory loss. Alzheimer's disease (AD) is the most common type of dementia. AD is linked …

Novel designer benzodiazepines: comprehensive review of evolving clinical and adverse effects

AN Edinoff, CA Nix, AS Odisho, CP Babin… - Neurology …, 2022 - mdpi.com
As tranquilizers, benzodiazepines have a wide range of clinical uses. Recently, there has
been a significant rise in the number of novel psychoactive substances, including designer …

Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

R Rupprecht, CH Wetzel, M Dorostkar, J Herms… - Molecular …, 2022 - nature.com
Efficient treatment of stress-related disorders, such as depression, is still a major challenge.
The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of …

[HTML][HTML] Lower urinary tract symptoms in depression: a review

DJ Anderson, A Aucoin, CR Toups… - Health psychology …, 2023 - ncbi.nlm.nih.gov
Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Insights on benzodiazepines' potential in Alzheimer's disease

HM Al-Kuraishy, AI Al-Gareeb, AA Alsayegh… - Life Sciences, 2023 - Elsevier
Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …

[HTML][HTML] Mental health and drug use in college students: Should we take action?

T Pérez, MC Pardo, Y Cabellos, M Peressini… - Journal of affective …, 2023 - Elsevier
Background College students are vulnerable to suffering from anxiety and depression.
Moreover, mental disorders can contribute to drug consumption or inappropriate use of …

Local and global effects of sedation in resting-state fMRI: a randomized, placebo-controlled comparison between etifoxine and alprazolam

S Wein, M Riebel, P Seidel, LM Brunner… - …, 2024 - nature.com
TSPO ligands are promising alternatives to benzodiazepines in the treatment of anxiety, as
they display less pronounced side effects such as sedation, cognitive impairment, tolerance …

Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1, 3, 4 …

A Fakhrioliaei, F Abedinifar, P Salehi Darjani… - BMC chemistry, 2023 - Springer
Background Epilepsy is a common neurological disorder. The available drugs for this
disease only control convulsions in nearly 70% of patients, while bearing many side effects …

The efficacy, safety, and adverse events of azapirones in anxiety disorders: A systematic review and meta-analysis of randomized controlled trials

F Rossano, C Caiazza, N Zotti, L Viacava… - European …, 2023 - Elsevier
Azapirones have been proposed as anxiety and mood modulators. We assessed
azapirones' viability in anxiety disorders via systematic review and random-effects meta …

[HTML][HTML] Have effective antidepressants finally arrived? Developments in major depressive disorder therapy

ME Thase - The Journal of Clinical Psychiatry, 2023 - psychiatrist.com
Among the greatest unmet needs in major depressive disorder (MDD) is a lack of effective
pharmacotherapies for patients who do not respond to first-and second-line antidepressant …