Current status and development prospects of aquatic vaccines

Y Du, X Hu, L Miao, J Chen - Frontiers in immunology, 2022 - frontiersin.org
Diseases are a significant impediment to aquaculture's sustainable and healthy growth. The
aquaculture industry is suffering significant financial losses as a result of the worsening …

Advances in infectious disease vaccine adjuvants

J Fan, S Jin, L Gilmartin, I Toth, WM Hussein… - Vaccines, 2022 - mdpi.com
Vaccines are one of the most significant medical interventions in the fight against infectious
diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the …

Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases

JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …

Saponins as natural emulsifiers for nanoemulsions

TB Schreiner, MM Dias, MF Barreiro… - Journal of agricultural …, 2022 - ACS Publications
The awareness of sustainability approaches has focused attention on replacing synthetic
emulsifiers with natural alternatives when formulating nanoemulsions. In this context, a …

Deciphering triterpenoid saponin biosynthesis by leveraging transcriptome response to methyl jasmonate elicitation in Saponaria vaccaria

X Chen, GA Hudson, C Mineo, B Amer… - Nature …, 2023 - nature.com
Methyl jasmonate (MeJA) is a known elicitor of plant specialized metabolism, including
triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese …

Cancer vaccines in the clinic

ME Janes, AP Gottlieb, KS Park, Z Zhao… - Bioengineering & …, 2024 - Wiley Online Library
Vaccines are an important tool in the rapidly evolving repertoire of immunotherapies in
oncology. Although cancer vaccines have been investigated for over 30 years, very few …

Understanding structure–function relationships of nanoadjuvants for enhanced cancer vaccine efficacy

J Tan, B Ding, B Teng, P Ma… - Advanced Functional …, 2022 - Wiley Online Library
Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …

Saponins as cytotoxic agents: An update (2010–2021). Part II—Triterpene saponins

I Podolak, K Grabowska, D Sobolewska… - Phytochemistry …, 2023 - Springer
Saponins make up an important group of natural glycosidic compounds which are
distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial …

Inhibiting angiogenesis by anti-cancer saponins: from phytochemistry to cellular signaling pathways

MB Majnooni, S Fakhri, SM Ghanadian, G Bahrami… - Metabolites, 2023 - mdpi.com
Saponins are one of the broadest classes of high-molecular-weight natural compounds,
consisting mainly of a non-polar moiety with 27 to 30 carbons and a polar moiety containing …

Vaccine approaches for antigen capture by liposomes

S Zhou, Y Luo, JF Lovell - Expert Review of Vaccines, 2023 - Taylor & Francis
Introduction Liposomes have been used as carriers for vaccine adjuvants and antigens due
to their inherent biocompatibility and versatility as delivery vehicles. Two vial admixture of …