Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune
cell types and are generally categorized into either of two functionally contrasting subtypes …

Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

The tumor development and metastasis are closely related to the structure and function of
the tumor microenvironment (TME). Recently, TME modulation strategies have attracted …

The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype
demonstrates great potential for remodeling the immunosuppressive tumor …

Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …