Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

AMPK (5′-AMP-activated protein kinase) is emerging as a metabolic master switch, by
which cells in both mammals and lower organisms sense and decode changes in energy …

The purpose of this study was to investigate myocardial substrate utilization during moderate
intensity exercise in humans. Coronary sinus and arterial catheters were inserted in nine …

Simple Summary The lens organ of the eye and muscle tissue exist at opposite ends of the
metabolic spectrum. Lens is metabolically quiescent using little energy, while muscle has …

1. The lowest contents of ATP and the lowest ATP/AMP concentration ratios are observed in
the molluscan muscles that have very low rates of energy expenditure during contraction …

1. An improved perfusion system for the isolated rat heart is described. It is based on the
isolated working heart of Neely, Liebermeister, Battersby & Morgan (1967)(Am. J. Physiol …

The human heart in the fasting state extracts FFA, glucose, lactate, pyruvate, and ketone
bodies from the systemic circulation. Of these substrates, FFA utilization accounts for the …

Glucose is an important substrate for myocardial metabolism. This study was designed to
determine the effect of circulating metabolic substrates on myocardial glucose extraction and …

1. The maximal activities of 5′-nucleotidase, adenosine kinase and adenosine deaminase
together with the Km values for their respective substrates were measured in muscle …

Ischemia of the myocardium results in a loss of ultrastructure and function. Tension
generation is diminished or abolished, electrolyte imbalance occurs, and the ATP …