Conclusions The isolated perfused rat heart has proved over many years to be a very useful
preparation for studies of myocardial metabolism and function, and is likely to remain so for …

1. The contents of the major purine nucleotides in the isolated non-working perfused rat
heart varied systematically during 80min of perfusion. In particular the amounts of ATP, ADP …

Three troponin T (TnT) mutants that cause hypertrophic, restrictive, and dilated
cardiomyopathy (I79N, ΔE96, and ΔK210, respectively), were examined using the thin …

Oxidation of several exogenous substrates by cultured adult rat ventricular cardiac muscle
cells has been assessed. Unlike freshly isolated cardiac muscle cells which oxidize glucose …

Four hypotheses to explain the several hundred fold activation of phosphofructokinase and
thus glycolysis in muscle during muscular contraction were examined. They are (1) Adenine …

Purpose Preconditioning in the setting of global ischemia, using functional recovery during
reperfusion as the endpoint, has recently been demonstrated in the isolated perfused rat …

31P nmr analysis of control and diabetic hearts perfused for 1 h with a glucose buffer
showed constant and normal levels of phosphocreatine and ATP. Supplementing the buffer …

We established a hyperthyroid rat model and compared the hemodynamic responses of the
hypertrophied rat heart in vivo and in vitro. Heart rate (557±26 beats/min), systolic blood …

The activity of several enzymes that contribute to the cellular adenylate energy charge and
the change in the total pool of adenine nucleotides were measured in groups of highly and …

To test a prediction that trans-sarcolemmal lactate movement is carrier mediated, 14 C-
labelled lactate or pyruvate and 3 H-mannitol were transiently infused (2 min) into …