Increasing heart workload stimulates glycolysis by enhancing glucose transport and fructose-
2, 6-bisphosphate (Fru-2, 6-P2), the latter resulting from 6-phosphofructo-2-kinase (PFK-2) …

We describe a method for perfusion of a working isolated rat heart with washed erythrocytes
suspended in a Krebs-Henseleit bicarbonate buffer containing bovine albumin (fraction V) …

Background Macrophages play a crucial role in the development of cardiac fibrosis (CF).
Although our previous studies have shown that glycogen metabolism plays an important role …

Some metabolic effects of increased mechanical activity by the Langendorff-perfused rat
heart have been characterized using 31 P-NMR. Mechanical activity was increased by …

Recombinant WT human cardiac actin (WT actin) was expressed using the
baculovirus/insect cell expression system, purified, and used to reconstitute the thin-filament …

Within one minute of acute coronary artery occlusion in the isolated rat heart performing
external mechanical work, cardiac output and left ventricular peak systolic pressure fell by …

Metabolic effects of increased mechanical work were studied by comparing isolated
pumping rat hearts perfused by the atrial-filling technique with aortic-perfused non-pumping …

ISCHAEMIA (Figs. 1–4) Initial metabolic studies concerning the effects of oxygen deprivation
on the heart were carried out in the perfused rat heart, where coronary flow was maintained …

This study tests the hypothesis that the efficacy of hypothermia as a cardiacprotective agent
can be increased by adding the slow channel-blocking agent, nifedipine. Isolated …

Cardiac myosin binding protein-C (cMyBP-C) is a cardiac-specific, thick-filament regulatory
protein that is differentially phosphorylated at Ser 273, Ser 282, and Ser 302 by various …