The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
SA Gillmor, A Villaseñor, R Fletterick, E Sigal… - Nature structural …, 1997 - nature.com
Here we report the first structure of a mammalian 15-lipoxygenase. The protein is composed
of two domains; a catalytic domain and a previously unrecognized β-barrel domain. The N …
of two domains; a catalytic domain and a previously unrecognized β-barrel domain. The N …
Peroxisome proliferator-activated receptors and inflammation
LA Moraes, L Piqueras, D Bishop-Bailey - Pharmacology & therapeutics, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARα …
receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARα …
Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution
Background High-resolution metabolomics (HRM) is emerging as a sensitive tool for
measuring environmental exposures and biological responses. The aim of this analysis is to …
measuring environmental exposures and biological responses. The aim of this analysis is to …
Peroxisome proliferator-activated receptors: insight into multiple cellular functions
P Escher, W Wahli - … Research/Fundamental and Molecular Mechanisms of …, 2000 - Elsevier
Peroxisome proliferator-activated receptors, PPARs,(NR1C) are nuclear hormone receptors
implicated in energy homeostasis. Upon activation, these ligand-inducible transcription …
implicated in energy homeostasis. Upon activation, these ligand-inducible transcription …
The nuclear receptor PPARγ and immunoregulation: PPARγ mediates inhibition of helper T cell responses
RB Clark, D Bishop-Bailey… - The Journal of …, 2000 - journals.aai.org
The peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors
belonging to the nuclear receptor superfamily. Until recently, the genes regulated by PPARs …
belonging to the nuclear receptor superfamily. Until recently, the genes regulated by PPARs …
Role of monocytes in atherogenesis
B Østerud, E Bjørklid - Physiological reviews, 2003 - journals.physiology.org
Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83:
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …
[HTML][HTML] Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle
L Perreault, SA Newsom, A Strauss, A Kerege… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Accumulation of diacylglycerol (DAG) and sphingolipids is thought to
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …
Differential expression of peroxisome proliferator-activated receptor-α,-β, and-γ during rat embryonic development
O Braissant, W Wahli - Endocrinology, 1998 - academic.oup.com
The expression patterns of the three different peroxisome proliferator-activated receptor
(PPAR) isotypes have been determined during rat embryonic development by in situ …
(PPAR) isotypes have been determined during rat embryonic development by in situ …
Medical significance of peroxisome proliferator-activated receptors
J Vamecq, N Latruffe - The Lancet, 1999 - thelancet.com
Peroxisome proliferator-activated receptors (PPAR) were discovered in 1990, ending 25
years of uncertainty about the molecular mechanisms of peroxisome proliferation …
years of uncertainty about the molecular mechanisms of peroxisome proliferation …
The role of leukotrienes in allergic diseases
M Liu, T Yokomizo - Allergology International, 2015 - jstage.jst.go.jp
abstract Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and
LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are …
LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are …