Alveolar macrophages exist in a unique microenvironment and, despite historical evidence
showing that they are in close contact with the respiratory epithelium, have until recently …

Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct
pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part …

Flow cytometry is used extensively to examine immune cells in non-lymphoid tissues.
However, a method of flow cytometric analysis that is both comprehensive and widely …

The lung hosts multiple populations of macrophages and dendritic cells, which play a crucial
role in lung pathology. The accurate identification and enumeration of these subsets are …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Phagocytosis, a critical early event in the microbicidal response of neutrophils, is now
appreciated to serve multiple functions in a variety of cell types. Professional phagocytes …

Clear identification of specific cell populations by flow cytometry is important to understand
functional roles. A well-defined flow cytometry panel for myeloid cells in human …

Influenza virus infection is a serious threat to humans and animals, with the potential to
cause severe pneumonia and death. Annual vaccination strategies are a mainstay to …

Activating mutations of K-ras are the most common oncogenic alterations found in lung
cancer. Unfortunately, attempts to target K-ras–mutant lung tumors have thus far failed …

Radiation-induced lung fibrosis (RIF) is a delayed side-effect of chest radiotherapy,
frequently associated with macrophage infiltration. We aimed to characterise the role of …