[HTML][HTML] The toxic mechanism of gliotoxins and biosynthetic strategies for toxicity prevention

W Ye, T Liu, W Zhang, W Zhang - International Journal of Molecular …, 2021 - mdpi.com
Gliotoxin is a kind of epipolythiodioxopiperazine derived from different fungi that is
characterized by a disulfide bridge. Gliotoxins can be biosynthesized by a gli gene cluster …

The many roles of sulfur in the fungal–host interaction

J Amich - Current Opinion in Microbiology, 2024 - Elsevier
Sulfur is an essential macronutrient for life, and consequently, all living organisms must
acquire it from external sources to thrive and grow. Sulfur is a constituent of a multitude of …

[HTML][HTML] Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion

SG Downes, RA Owens, K Walshe, DA Fitzpatrick… - Scientific Reports, 2023 - nature.com
Overcoming antimicrobial resistance represents a formidable challenge and investigating
bacterial growth inhibition by fungal metabolites may yield new strategies. Although the …

[HTML][HTML] Unravelling the modes of action of autochthonous staphylococci against Aspergillus westerdijkiae and the antiochratoxigenic effect in dry-cured ham

E Cebrián, M Rodríguez, M Álvarez, J Delgado… - LWT, 2024 - Elsevier
Aspergillus westerdijkiae is well known for its capacity to produce high amounts of
ochratoxin A (OTA) in dry-cured ham. Some autochthonous microorganisms, such as …

[HTML][HTML] Regulation of pseurotin A biosynthesis by GliZ and zinc in Aspergillus fumigatus

H Seo, S Kang, D Lee, CW Yun - Scientific reports, 2023 - nature.com
Recently, we reported that zinc regulates gliotoxin biosynthesis via ZafA, which is a zinc-
responsive transcriptional activator. From an HPLC analysis of culture media of Aspergillus …

[HTML][HTML] Regulation of gliotoxin biosynthesis and protection in Aspergillus species

PA de Castro, AC Colabardini, M Moraes… - PLoS …, 2022 - journals.plos.org
Aspergillus fumigatus causes a range of human and animal diseases collectively known as
aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of …

Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response

E Abraham, AMGK Athapaththu… - ACS Chemical …, 2024 - ACS Publications
C. elegans numr-1/2 (nu clear-localized m etal-r esponsive) is an identical gene pair
encoding a nuclear protein previously shown to be activated by cadmium and disruption of …

[HTML][HTML] Fungal Zinc Homeostasis and Its Potential as an Antifungal Target: A Focus on the Human Pathogen Aspergillus fumigatus

P Zhai, Y Chai, L Lu - Microorganisms, 2022 - mdpi.com
Aspergillus fumigatus is an opportunistic airborne fungus that causes severe invasive
aspergillosis in immunocompromised patients. Zinc is an essential micronutrient for the …

Aspergillus fumigatus ZrfC Zn (ii) transporter scavengers zincophore-bound Zn (ii)

K Garstka, G Potoczniak, H Kozłowski… - Dalton …, 2024 - pubs.rsc.org
Aspergillus fumigatus is an opportunistic pathogen that is able to invade and grow in the
lungs of immunosuppressed patients and cause invasive pulmonary aspergillosis. The …

Characterization of Aspergillus fumigatus secretome during sublethal infection of Galleria mellonella larvae

A Curtis, P Dobes, J Marciniak… - Journal of Medical …, 2024 - microbiologyresearch.org
Introduction. The fungal pathogen Aspergillus fumigatus can induce prolonged colonization
of the lungs of susceptible patients, resulting in conditions such as allergic …