Tumor microenvironment in prostate cancer: toward identification of novel molecular biomarkers for diagnosis, prognosis, and therapy development

HF Bahmad, M Jalloul, J Azar, MM Moubarak… - Frontiers in …, 2021 - frontiersin.org
Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …

Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastases

AL Hardaway, MK Herroon, E Rajagurubandara… - Cancer and Metastasis …, 2014 - Springer
Adipocytes are important but underappreciated components of bone marrow
microenvironment, and their numbers greatly increase with age, obesity, and associated …

Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and …

KL Inder, JE Ruelcke, L Petelin, H Moon… - Journal of …, 2014 - Taylor & Francis
Background Tumour-derived extracellular vesicles (EVs) play a role in tumour progression;
however, the spectrum of molecular mechanisms regulating EV secretion and cargo …

A pH‐sensitive, biobased calcium carbonate aragonite nanocrystal as a novel anticancer delivery system

A Shafiu Kamba, M Ismail… - BioMed research …, 2013 - Wiley Online Library
The synthesised biobased calcium carbonate nanocrystals had demonstrated to be an
effective carrier for delivery of anticancer drug doxorubicin (DOX). The use of these …

Bisphosphonates or RANK‐ligand‐inhibitors for men with prostate cancer and bone metastases: a network meta‐analysis

T Jakob, YM Tesfamariam, S Macherey… - Cochrane Database …, 2020 - cochranelibrary.com
Background Different bone‐modifying agents like bisphosphonates and receptor activator of
nuclear factor‐kappa B ligand (RANKL)‐inhibitors are used as supportive treatment in men …

Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy

M Hassanshahi, A Hassanshahi, S Khabbazi, YW Su… - Angiogenesis, 2017 - Springer
It is very well known that bone marrow (BM) microvasculature may possess a crucial role in
the maintenance of homeostasis of BM due to mutual interactions between BM …

Prostate cancer with bone metastasis in Beijing: an observational study of prevalence, hospital visits and treatment costs using data from an administrative claims …

L Zhuo, Y Cheng, Y Pan, J Zong, W Sun, L Xu… - BMJ open, 2019 - bmjopen.bmj.com
Objectives To estimate the prevalence of prostate cancer with bone metastasis in Beijing,
and to estimate hospital visits and direct treatment costs among male urban employees with …

Advanced prostate cancer: reinforcing the strings between inflammation and the metastatic behavior

G Gueron, A De Siervi, E Vazquez - Prostate Cancer and Prostatic …, 2012 - nature.com
It is currently estimated that inflammatory responses are linked to 15–20% of all deaths from
cancer worldwide. Although many studies point to an important role of inflammation in …

Targeting integrin α6 stimulates curative-type bone metastasis lesions in a xenograft model

TH Landowski, J Gard, E Pond, GD Pond… - Molecular cancer …, 2014 - AACR
Laminin-binding integrin receptors are key mediators of epithelial cell migration and tumor
metastasis. Recent studies have demonstrated a role for the α6 integrin (ITGA6/CD49f) in …

11C-choline PET/CT identifies osteoblastic and osteolytic lesions in patients with metastatic prostate cancer

F Ceci, P Castellucci, T Graziani… - Clinical nuclear …, 2015 - journals.lww.com
Aim The aim of this study was to compare 11 C-choline PET/CT, prostate-specific antigen
(PSA), PSA kinetics, and 11 C-choline uptake in recurrent metastatic prostate cancer …