Patients diagnosed with advanced prostate cancer (PCa) often experience incurable bone
metastases; however, a lack of relevant experimental models has hampered the study of …

Metastatic prostate cancer (PCa) has high mortality and a poor 5-year survival rate primarily
due to the lack of effective treatments. Bone is the primary site of PCa metastasis in humans …

A green and efficient straightforward tactic for the one-pot regioselective synthesis of novel
10, 10-dimethyl-9, 10, 11, 11a-tetrahydro-6H-spiro [chromeno [4, 3–b] chromene-7, 3 …

Prostate cancer (PCa) is the most common solid organ malignancy among men,
outnumbering both lung and colorectal cancer, and it is the second leading cause of male …

Castration-resistant prostate cancer remains a significant clinical challenge, wherein
patients display no response to existing hormone therapies. The standard of care often …

Prostate cancer (PC) is one of the most common cancers arising in men and has a high
propensity for bone metastasis, particularly to the spine. At this stage, it often causes severe …

Background Advanced prostate cancer commonly metastasizes to bone leading to
osteoblastic and osteolytic lesions. Although an osteolytic component governed by …

Accumulating evidence highlights the importance of interactions between tumour cells and
stromal cells for tumour initiation, progression, and metastasis. In tumours that contain …

Cancer metastasis is the cause of most cancer related deaths and many cancers are
becoming resistant to current therapies. An alternative approach is to investigating signalling …

Head and neck cancers (HNCs) rank as the sixth most common cancer globally and result in
over 450 000 deaths annually. Despite considerable advancements in diagnostics and …