Donor and recipient polygenic risk scores influence the risk of post-transplant diabetes

A Shaked, BL Loza, E Van Loon, KM Olthoff, W Guan… - Nature Medicine, 2022 - nature.com
Post-transplant diabetes mellitus (PTDM) reduces allograft and recipient life span. Polygenic
risk scores (PRSs) show robust association with greater risk of developing type 2 diabetes …

Xenotransplantation: progress along paths uncertain from models to application

JL Platt, M Cascalho, JA Piedrahita - ILAR journal, 2018 - academic.oup.com
For more than a century, transplantation of tissues and organs from animals into man,
xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest …

[HTML][HTML] Systems biology in kidney transplantation: the application of multi-omics to a complex model

SV Bontha, DG Maluf, TF Mueller, VR Mas - American Journal of …, 2017 - Elsevier
In spite of reduction of rejection rates and improvement in short-term survival post–kidney
transplantation, modest progress has occurred in long-term graft attrition over the years …

Long‐and short‐term outcomes in renal allografts with deceased donors: a large recipient and donor genome‐wide association study

MP Hernandez‐Fuentes, C Franklin… - American Journal of …, 2018 - Wiley Online Library
Improvements in immunosuppression have modified short‐term survival of deceased‐donor
allografts, but not their rate of long‐term failure. Mismatches between donor and recipient …

Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients

EY Tamashiro, CR Felipe, FDV Genvigir… - Drug metabolism and …, 2017 - degruyter.com
Background: Polymorphisms in genes encoding for drug-metabolizing enzymes and drug
transporters are among multiple factors that modulate the pharmacokinetic variability of …

Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms

P Jethwani, A Rao, L Bow, MC Menon - Frontiers in Immunology, 2022 - frontiersin.org
Despite significant improvement in the rates of acute allograft rejection, proportionate
improvements in kidney allograft longevity have not been realized, and are a source of …

[HTML][HTML] Single nucleotide polymorphisms and long-term clinical outcome in renal transplant patients: a validation study

HK Pihlstrøm, G Mjøen, S Mucha, G Haraldsen… - American Journal of …, 2017 - Elsevier
Genome-wide association studies (GWAS) are designed to investigate single nucleotide
polymorphisms (SNPs) and the association with a clinical phenotype. A previous GWAS …

[HTML][HTML] Non-HLA donor–recipient mismatches in kidney transplantation—A stone left unturned

S Farouk, Z Zhang, MC Menon - American Journal of Transplantation, 2020 - Elsevier
In kidney transplantation, short-term allograft survival has improved due to improvements in
acute rejection episodes without corresponding improvements in long-term survival …

Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus

Z Abdelrahman, AP Maxwell, AJ McKnight - Genes, 2024 - mdpi.com
Post-transplant diabetes mellitus (PTDM) is a common complication of solid organ
transplantation. PTDM prevalence varies due to different diabetes definitions. Consensus …

Biomarkers and pharmacogenomics in kidney transplantation

LE Crowley, M Mekki, S Chand - Molecular diagnosis & therapy, 2018 - Springer
This review is focused on present and future biomarkers, along with pharmacogenomics
used in clinical practice for kidney transplantation. It aims to highlight biomarkers that could …