Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

The management of gout consists of urate-lowering therapy and acute and chronic anti-
inflammatory drugs. Allopurinol, a xanthine oxidase inhibitor, is the primary urate-lowering …

Serum albumin is glycated in diabetic or hyperglycemic conditions. For in vitro experiments
bovine serum albumin (BSA) is employed as a transport protein. So, in this work, we aim to …

In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2)
transports milk calcium. Its expression is activated in breast cancers, where high tumor …

Introduction The acute gout flare results from a localised self-limiting innate immune
response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic …

Aims The primary aim of this research was to predict the allopurinol maintenance doses
required to achieve the target plasma urate of≤ 0.36 mmol l− 1. Methods A population …

Allopurinol, which lowers uric acid (UA) concentration, is increasingly being recognized for
its benefits in cardiovascular and renal disease. However, response to allopurinol is …

To develop a more effective and safer treatment for Hyperuricemia (HUA), this research
investigated the anti-hyperuricemic mechanism of KGM from the perspectives of uric acid …

The missense variant, breast cancer resistance protein (BCRP) p. Q141K, which encodes a
reduced function BCRP, has been linked to poor response to allopurinol. Using a …

Aims This study aimed to develop and evaluate an allopurinol adherence tool based on
steady‐state oxypurinol plasma concentrations, allopurinol's active metabolite. Methods …