The transcriptional upregulation of oncogenes is a driving force behind the progression of
many tumours. However, until a decade ago, the concept of 'switching off'these oncogenic …

Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Squamous cell lung cancers (lung squamous cell carcinomas [LUSCs]) are associated with
high mortality and a lack of therapies specific to this disease. Although recurrent molecular …

The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …

Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly
aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often …

Germline inactivating mutations in SMARCA4 (SWI/SNF-related, matrix-associated, actin-
dependent regulator of chromatin, subfamily A, member 4) gene encoding for BRG1 …

Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is
associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and …

Abstract Introduction Ten percent of NSCLCs harbor mutations in SMARCA4, the gene
encoding the SWItch/Sucrose Non-Fermentable ATPase BRG1. In preclinical models, BRG1 …

NUT carcinoma, also known as NUT midline carcinoma, is an aggressive malignancy mainly
affecting the midline structures of younger patients and almost invariably leading to death …