Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts
before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells
damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role …

Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …

It has become a current social trend for women to delay childbearing. However, the quality of
oocytes from older females is compromised and the pregnancy rate of older women is lower …

Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis,
which involves enhancement of the transcriptional activity of the pro-apoptotic factor …

Female fertility irreversibly declines with aging, and this is primarily associated with the
decreased quality and quantity of oocytes. To evaluate whether a long‐term of melatonin …

Resveratrol is one of the most investigated natural polyphenolic compounds and is
contained in more than 70 types of plants and in red wine. The widespread interest in this …