Cardiovascular disease is a leading cause of death, and translational research is needed to
understand better mechanisms whereby the left ventricle responds to injury. Mouse models …

Heart failure (HF) is a leading cause of morbidity and mortality in the United States. Despite
a number of important therapeutic advances for the treatment of symptomatic HF, 1 the …

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac
function in clinical and experimental research. Significant progress in the development of …

Rapamycin has been shown to extend lifespan in numerous model organisms including
mice, with the most dramatic longevity effects reported in females. However, little is known …

Rationale: In response to injury, the rodent heart is capable of virtually full regeneration via
cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished …

Background: The nitric oxide–sensitive guanylyl cyclase/cGMP-dependent protein kinase
type I signaling pathway can afford protection against the ischemia/reperfusion injury that …

Increasing evidence indicates the involvement of myocardial oxidative injury and
mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate …

Objectives: This study sought to investigate the hypothesis that the favorable effects of
mesenchymal stromal cells (MSCs) on infarct repair are mediated by macrophages …

Background Cardiac remodeling is one of the major risk factors for heart failure. In patients
with type 2 diabetes, sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of …

We report a nanoparticulate system capable of targeting the heart after myocardial infarction
(MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the …