Recent cardiotropic drug developments have focused on cardiac myofilaments. Danicamtiv,
the second direct myosin activator, has achieved encouraging results in preclinical and …

Background—Heart failure is one of the leading causes of mortality and is primarily the final
stage of several overload cardiomyopathies, preceded by an early adaptive hypertrophic …

Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients
with chronic kidney disease (CKD), but the underlying mechanisms contributing to this …

Enhanced sensitivity in echocardiographic analyses may allow for early detection of
changes in cardiac function beyond the detection limits of conventional echocardiographic …

Background The subendocardium is highly vulnerable to damage and is thus affected even
in subclinical disease stages. Therefore, methods reflecting subendocardial status are of …

Photoacoustic imaging (PAI) is an evolving real-time imaging modality that combines the
higher contrast of optical imaging with the higher spatial resolution of ultrasound imaging …

Background Human mesenchymal stromal cells (hMSC s) from adipose cardiac tissue have
attracted considerable interest in regard to cell‐based therapies. We aimed to test the …

Emerging clinical data support the notion that RV dysfunction is critical to the pathogenesis
of cardiovascular disease and heart failure1-3. Moreover, the RV is significantly affected in …

Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise
training seems to prevent doxorubicin-induced cardiac damage. However, the effectiveness …

Objectives The ventricle undergoes adverse remodeling after myocardial infarction, resulting
in abnormal biomechanics and decreased function. We hypothesize that tissue-engineered …