[HTML][HTML] Understanding acquired brain injury: a review

L Goldman, EM Siddiqui, A Khan, S Jahan… - Biomedicines, 2022 - mdpi.com
Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI).
In general, ABI does not result from congenital disorders, degenerative diseases, or by brain …

[HTML][HTML] Inflammasome activation in traumatic brain injury and Alzheimer's disease

NH Johnson, JP de Rivero Vaccari, HM Bramlett… - Translational …, 2023 - Elsevier
Traumatic brain injury (TBI) and Alzheimer's disease (AD) represent 2 of the largest sources
of death and disability in the United States. Recent studies have identified TBI as a potential …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …

[HTML][HTML] Revisiting excitotoxicity in traumatic brain injury: from bench to bedside

D Baracaldo-Santamaría, DF Ariza-Salamanca… - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …

[HTML][HTML] TGF-β as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications

J Luo - Biomedicines, 2022 - mdpi.com
Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Neuroinflammatory biomarkers for traumatic brain injury diagnosis and prognosis: A TRACK-TBI pilot study

JK Yue, FH Kobeissy, S Jain, X Sun… - Neurotrauma …, 2023 - liebertpub.com
The relationship between systemic inflammation and secondary injury in traumatic brain
injury (TBI) is complex. We investigated associations between inflammatory markers and …

[HTML][HTML] Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?

MAM Freire, GS Rocha, LO Bittencourt, D Falcao… - Biology, 2023 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …

URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated …

DP Wang, K Kang, J Sun, Q Lin… - Oxidative Medicine and …, 2022 - Wiley Online Library
Ischemic stroke, a cerebrovascular disease worldwide, triggers a cascade of
pathophysiological events, including blood‐brain barrier (BBB) breakdown. Brain …

Exosomes derived from bone marrow mesenchymal stem cells attenuate neurological damage in traumatic brain injury by alleviating glutamate-mediated …

Z Zhuang, M Liu, J Luo, X Zhang, Z Dai, B Zhang… - Experimental …, 2022 - Elsevier
Background Traumatic brain injury (TBI) is one of the major contributors to disability and
death worldwide. Glutamate-mediated excitotoxicity, one of the secondary injuries occurring …

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

B Hakiminia, B Alikiaii, F Khorvash… - Fundamental & …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …