Although androgens and the androgen receptor (AR) have defining roles in male
reproductive development and function, previously no role in female reproductive …

For many decades, elevated androgens in women have been associated with poor
reproductive health. However, recent studies have shown that androgens play a crucial role …

Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary
syndrome, is often associated with disturbed reproductive performance, androgens have …

Androgens/androgen receptor (AR) signaling is involved primarily in the development of
male-specific phenotypes during embryogenesis, spermatogenesis, sexual behavior, and …

Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated
hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and …

Ovarian granulosa cells display strong androgen receptor (AR) expression, suggesting a
functional role for direct AR-mediated actions within developing mammalian follicles. By …

Abstract Estradiol-17β (E2) affects late follicular development, whereas primordial follicle
differentiation and early activation are believed to be independent of E2. To test this …

Preimplantation development directs the formation of an implantation-or attachment-
competent embryo so that metabolic interactions with the uterus can occur, pregnancy can …

A first step to elucidating the roles that steroids may play in the processes of ovarian
development and early follicular growth is to identify the cell types that are likely to be …

In this study, we test the hypothesis that the growth-promoting action of androgens on
granulosa cells requires paracrine signaling from the oocyte. Mural granulosa cells (MGCs) …