The 'MHC-I (major histocompatibility complex class I)-opathy'concept describes a family of
inflammatory conditions with overlapping clinical manifestations and a strong genetic link to …

Abstract Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved
in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that …

Juvenile idiopathic arthritis (JIA) is an autoimmune, inflammatory joint disease with complex
genetic etiology. Previous GWAS have found many genetic loci associated with JIA …

Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various
autoimmune conditions, as well as protection against lethal infections. Due to high linkage …

A strong genetic predictor of outcome following untreated HIV-1 infection is the carriage of
specific alleles of human leukocyte antigens (HLAs) that present viral epitopes to T cells …

Recent studies have linked the activity of ER aminopeptidase 2 (ERAP2) to increased
efficacy of immune-checkpoint inhibitor cancer immunotherapy, suggesting that …

Human leukocyte antigen (HLA) class I association is a well-established feature of common
and uncommon inflammatory diseases, but it is unknown whether it impacts the …

Liver cancer, particularly hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), is
more common in Asians than in Caucasians. This is due, at least in part, to regional …

Abstract ER aminopeptidase 1 (ERAP1) is an ER‐resident aminopeptidase that excises N‐
terminal residues of peptides that then bind onto Major Histocompatibility Complex I …

Objective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a
complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an …