Alternative splicing is often deregulated in cancer, and cancer-specific isoform switches are
part of the oncogenic transformation of cells. Accumulating evidence indicates that isoforms …

Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we
illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly …

Cancer drug resistance is a common, unpredictable phenomenon that develops in many
types of tumors, resulting in the poor efficacy of current anticancer therapies. One of the most …

Background: T cell exhaustion (TEX) is an important immune escape mechanism, and an in-
depth understanding of it can help improve cancer immunotherapy. However, the prognostic …

Methotrexate (MTX)-induced gastrointestinal mucositis is a common adverse effect
characterized by redox imbalance and overproduction of inflammatory mediators that …

Objective To explore the intrinsic mechanism of the mammalian target of rapamycin (mTOR)
pathway activation and promotion of neuronal axon growth. Methods Human neuroblastoma …

In the past few decades, personalized therapies have severely improved the outcome of
patients with advanced-stage lung adenocarcinoma, yet so far the search for similarly …

Während das Frühjahrstreffen 2022 der Arbeitsgemeinschaft (AG) Thoraxpathologie noch in
digitaler Form stattfinden musste, war im Juni im Rahmen der Jahrestagung der Deutschen …

Due to the complexity of both genetic and epigenetic factors underlying the initiation and
progression of tumorigenesis, contemporary anticancer therapies are still not very effective …

Während das Frühjahrstreffen 2022 der Arbeitsgemeinschaft (AG) Thoraxpathologie noch in
digitaler Form stattfinden musste, war im Juni im Rahmen der Jahrestagung der Deutschen …