Immune checkpoint inhibitors in challenging populations
Immune checkpoint inhibitors, including those targeting the programmed cell death
1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are …
1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are …
Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
T Pentcheva‐Hoang, E Corse… - Immunological …, 2009 - Wiley Online Library
The generation of productive adaptive immune responses depends on the antigen‐specific
activation of T and B cells. The outcome of T‐cell receptor engagement is influenced by …
activation of T and B cells. The outcome of T‐cell receptor engagement is influenced by …
Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells
JF Grosso, MV Goldberg, D Getnet… - The Journal of …, 2009 - journals.aai.org
Abstract Lymphocyte Activation Gene-3 (LAG-3) is a transmembrane protein that binds MHC
class II, enhances regulatory T cell activity, and negatively regulates cellular proliferation …
class II, enhances regulatory T cell activity, and negatively regulates cellular proliferation …
B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders
RA Wilcox, AL Feldman, DA Wada… - Blood, The Journal …, 2009 - ashpublications.org
Stromal elements present within the tumor microenvironment may suppress host immunity
and promote the growth of malignant lymphocytes in B cell–derived non-Hodgkin lymphoma …
and promote the growth of malignant lymphocytes in B cell–derived non-Hodgkin lymphoma …
[PDF][PDF] Chronically inflamed livers up‐regulate expression of inhibitory B7 family members
R Kassel, MW Cruise, JC Iezzoni, NA Taylor… - …, 2009 - Wiley Online Library
Hepatitis B virus, hepatitis C virus, autoimmune hepatitis, and nonalcoholic fatty liver
disease can induce chronic liver disease. The Programmed Death‐1 (PD‐1) inhibitory …
disease can induce chronic liver disease. The Programmed Death‐1 (PD‐1) inhibitory …
Programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in viral hepatitis
Virus-specific cluster of differentiation 8 (CD8+) cytotoxic T cells (CTL) recognize viral
antigens presented on major histocompatibility complex (MHC) class I chains on infected …
antigens presented on major histocompatibility complex (MHC) class I chains on infected …
Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion
SD Blackburn, A Crawford, H Shin, A Polley… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT The PD-1/PD-L pathway plays a major role in regulating T-cell exhaustion
during chronic viral infections in animal models, as well as in humans, and blockade of this …
during chronic viral infections in animal models, as well as in humans, and blockade of this …
Bioinformatics analyses of significant genes, related pathways, and candidate diagnostic biomarkers and molecular targets in SARS-CoV-2/COVID-19
B Vastrad, C Vastrad, A Tengli - Gene Reports, 2020 - Elsevier
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection is a leading
cause of pneumonia and death. The aim of this investigation is to identify the key genes in …
cause of pneumonia and death. The aim of this investigation is to identify the key genes in …
Hepatitis C virus induces MDSCs-like monocytes through TLR2/PI3K/AKT/STAT3 signaling
N Zhai, H Li, H Song, Y Yang, A Cui, T Li, J Niu… - PLoS …, 2017 - journals.plos.org
Background and Aims Recent studies reveal the accumulation of myeloid derived
suppressor cells (MDSCs) in human peripheral blood mononuclear cells (PBMCs) following …
suppressor cells (MDSCs) in human peripheral blood mononuclear cells (PBMCs) following …
PD‐1 negatively regulates interleukin‐12 expression by limiting STAT‐1 phosphorylation in monocytes/macrophages duringchronic hepatitis C virus infection
CJ Ma, L Ni, Y Zhang, CL Zhang, XY Wu, AN Atia… - …, 2011 - Wiley Online Library
Hepatitis C virus (HCV) is remarkably efficient at evading host immunity to establish chronic
infection. During chronic HCV infection, interleukin‐12 (IL‐12) produced by monocytes …
infection. During chronic HCV infection, interleukin‐12 (IL‐12) produced by monocytes …