PharmVar GeneFocus: CYP2D6

C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

PharmVar GeneFocus: CYP2C19

MR Botton, M Whirl‐Carrillo… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele
nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation …

[HTML][HTML] Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19

AB Koopmans, MH Braakman, DJ Vinkers… - Translational …, 2021 - nature.com
Extensive migration has led to the necessity of knowledge regarding the treatment of
migrants with different ethnical backgrounds. This is especially relevant for pharmacological …

[HTML][HTML] A scoping review of guidelines for the use of race, ethnicity, and ancestry reveals widespread consensus but also points of ongoing disagreement

M Mauro, DS Allen, B Dauda, SJ Molina… - The American Journal of …, 2022 - cell.com
The use of population descriptors such as race, ethnicity, and ancestry in science, medicine,
and public health has a long, complicated, and at times dark history, particularly for genetics …

PharmVar GeneFocus: CYP2C9

K Sangkuhl, K Claudio‐Campos… - Clinical …, 2021 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele
nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the …

PharmVar GeneFocus: CYP3A5

C Rodriguez‐Antona, JL Savieo… - Clinical …, 2022 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature
for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus …

Health equality, race and pharmacogenomics

EF Magavern, D Gurdasani, FL Ng… - British journal of clinical …, 2022 - Wiley Online Library
Pharmacogenomics is increasingly moving into mainstream clinical practice. Careful
consideration must be paid to inclusion of diverse populations in research, translation and …

Pharmacogenomics in Asian subpopulations and impacts on commonly prescribed medications

C Lo, S Nguyen, C Yang, L Witt, A Wen… - Clinical and …, 2020 - Wiley Online Library
Asians as a group comprise> 60% the world's population. There is an incredible amount of
diversity in Asian and admixed populations that has not been addressed in a …

[HTML][HTML] CYP2D6 overview: allele and phenotype frequencies

M Kane - Medical Genetics Summaries [Internet], 2021 - ncbi.nlm.nih.gov
Genetic variation has a significant impact on an individual's metabolism and response to a
wide range of medications. The cytochrome P450 family of enzymes are key determinants in …

A review of clinical pharmacogenetics Studies in African populations

F Radouani, L Zass, Y Hamdi, J Rocha… - Personalized …, 2020 - Taylor & Francis
Effective interventions and treatments for complex diseases have been implemented
globally, however, coverage in Africa has been comparatively lower due to lack of capacity …