Cardiac remodeling is generally accepted as a determinant of the clinical course of heart
failure (HF). Defined as genome expression resulting in molecular, cellular and interstitial …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Aims Biomarkers are increasingly being used in the management of patients with chronic
heart failure (HF). Galectin-3 is a recently developed biomarker associated with fibrosis and …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Aims Conventional late gadolinium enhancement (LGE) cardiac magnetic resonance can
detect myocardial infarction and some forms of non-ischaemic myocardial fibrosis. However …

In this study changes in the amount and distribution of types I and III collagen mRNA and
protein were investigated in the rat heart after induction of a left ventricular myocardial …

Purpose To determine the utility of cardiac magnetic resonance (MR) T1 mapping for
quantification of diffuse myocardial fibrosis compared with the standard of endomyocardial …

Infarct scar, a requisite to the rebuilding of necrotic myocardium following myocardial
infarction (MI), has long been considered inert. Earlier morphologic studies suggested …

Interstitial cells in the scars of human myocardial infarctions of different postinfarction times
(6 hours to 17 years old) were characterized by antibodies to alpha-smooth muscle actin …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …