Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Microneedles have attracted increasing interest among various medical fields due to their
painless, noninvasive, and efficient way of drug delivery. However, practical applications of …

Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …

HtrA1 (High temperature requirement A1) family proteins include four members, widely
conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a …