Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …

Acute inflammatory responses are protective, yet without timely resolution can lead to
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …

The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …

Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in
phospholipids in the brain and retina, is known to play multi-functional roles in brain health …

Essential fatty acids can serve as important regulators of inflammation. A new window into
mechanisms for the resolution of inflammation was opened with the identification and …

Epidemiological, human, animal, and cell culture studies show that n− 3 fatty acids,
especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid …

Phospholipase A 2 s are enzymes that hydrolyze the fatty acid at the sn-2 position of the
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …

The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and
PON3. Their physiological role (s) and natural substrates are uncertain. We developed a …

Abstract Omega-3-polyunsaturated fatty acids (ω-3-PUFAs) have well-documented
protective effects that are attributed not only to eicosanoid inhibition but also to the formation …