Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Several genetic causes
of ASD have been identified and this has enabled researchers to construct mouse models …

The continuing fascination with serotonin (5‐hydroxytryptamine, 5‐HT) as a nervous system
chemical messenger began with its discovery in the brains of mammals in 1953. Among the …

A variety of human and animal studies support the hypothesis that serotonin (5-
hydroxytryptamine or 5-HT) system dysfunction is a contributing factor to the development of …

Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R)
in the brain physiology and pathology have advanced considerably in recent years. A wealth …

Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

Gastrointestinal (GI) comorbidities are common in individuals with mood and behavioral
dysfunction. Similarly, patients with GI problems more commonly suffer from co-morbid …